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Why Symprove

Symprove is a unique, water-based food supplement. It contains four strains of live and active bacteria. These are delivered to the gut to support the microbiome.1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.,2Moens F, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm 2019;555:1-10. Symprove should be taken as part of a healthy lifestyle.

What is Symprove?

Symprove bottle hero straight

Symprove is a unique, water-based food supplement. It contains four strains of live and activated bacteria. These are delivered to the gut to support the microbiome1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.,2Moens F, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm 2019;555:1-10.. Symprove should be taken as part of a healthy lifestyle.

Only Symprove arrives, survives and thrives in the gut

University College London researchers studied a range of bacteria-containing food supplements. Only Symprove passed all three of their tests:1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.

  • Arriving in the stomach in a viable state
  • Surviving exposure to gastric juices
  • Thriving and colonising the gut wall and starting to grow

Successfully delivering live bacteria to the gut to support the microbiome

Symprove bacteria - Arrive

Arrive in the stomach 

Symprove bacteria arrive live and active in the stomach, at the amount stated on the label.1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.

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Symprove bacteria - Survive

Survive passage through the stomach and small intestine 

Symprove bacteria survive upon exposure to the harsh gastric and small intestinal conditions.1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.,2Moens F, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm 2019;555:1-10.

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Symprove bacteria - Thrive

Thrive in the colon

All Symprove bacteria enter the colon in a live state and are present in the colon. They remain metabolically active in the colon, as demonstrated through the production of lactic acid.2Moens F, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm 2019;555:1-10.

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Symprove bacteria - Drive

Drive the colonic microbiome

Through production of lactate, Symprove feeds the host bacteria to drive microbiome balance.2Moens F, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm 2019;555:1-10.

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Arrive

Using an in vitro approach that closely matches oral delivery in vivo, a key study compared Symprove with seven other market-leading products.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151

Symprove arrive survive thrive drive end
In transit to the stomach, freeze dried supplements lost more than 70% of their bacteria compared with Symprove.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151.
The bacteria of the two dairy-based products reached the stomach.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151.
Symprove bacteria - Arrive
100% of the Symprove bacteria arrive live and active in the stomach, at the amount stated on the label.1Fredua-Agyeman M and Gaisford S. Comparative survival of commercial probiotic formulations: Tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Beneficial Microbes 2015;6(1):141-151.
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Survive

An in vitro approach that closely matches oral delivery in vivo demonstrated how well Symprove and seven other market-leading products survive exposure to the harsh conditions of the stomach.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151.

Symprove arrive survive thrive drive end
The bacteria in Symprove survived exposure to gastric fluid. However, in some of the other products, none of the bacteria survived.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151.
Only two products (one of which was Symprove) survived the stomach transit time of two hours.1Fredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. 2015;6(1):141–151.
Symprove bacteria - Survive
More recently an in vitro model of the human gastrointestinal tract demonstrated that exposure to stomach acid for 45 minutes and bile salts and pancreatic fluid for three hours did not reduce the number of viable bacteria in Symprove.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.
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Thrive

Results from an in vitro model of the human gastrointestinal tract show how the bacteria in Symprove establish themselves along the entire length of the colon.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.

Symprove arrive survive thrive drive end
The four bacteria strains in Symprove enter the colon in a live state and colonise the entire colon.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.
They remain metabolically active before going on to multiply and thrive.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.
Symprove bacteria - Thrive
Symprove arrive survive thrive drive end

Drive

Once in the colon, Symprove is still metabolically active, creating multiple effects that help drive balance in the microbiome through:2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.

Symprove arrive survive thrive drive end
The bacteria starting to produce their major end-metabolite lactate.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.
An increase in the production of short-chain fatty acids.2Moens F, Van den Abbeele P, Basit AW, et al. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J Pharm. 2019;555:1–10.
Symprove bacteria - Drive
A significant reduction in the concentration of adherent-invasive E.coli (AIEC) after 24-hour and 48-hour incubation periods in a dose-dependent fashion.3Prodigest Data on File 2017.
Symprove arrive survive thrive drive end

Symprove’s four bacteria

The 4 Symprove water-borne bacteria
The four live bacteria strains in Symprove are:
  • Lactobacillus rhamnosus NCIMB 30174
  • Enterococcus faecium NCIMB 30176
  • Lactobacillus acidophilus NCIMB 30175
  • Lactobacillus plantarum NCIMB 30173

Symprove delivers 10 billion colony forming units of bacteria per 70 ml of product, consistent with the amount used in human clinical research trials.

Learn more about the bacteria in Symprove:

Various types of these bacteria are found in the human gastrointestinal tract.3Goldstein E, et al. Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities. Clin Infect Dis 2015;60(2):S98-S107. The three strains included in Symprove all have a history of being used in food, including fermented milk and food supplements, starters for Emmental cheese and the fermentation of vegetables.4Symprove quality and safety dossier 2017 The European Food Safety Authority (EFSA) has added these three species to the Qualified Presumption of Safety list.3Goldstein E, et al. Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities. Clin Infect Dis 2015;60(2):S98-S107.

These bacteria are commonly found in human and animal microbiomes.3Goldstein E, et al. Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities.Clin Infect Dis 2015;60(2):S98-S107. They also have a history of being used in food, such as cheese,3Goldstein E, et al. Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities. Clin Infect Dis 2015;60(2):S98-S107. and are thought to have a flavour-enhancing effect.5Gelsomino R, et al. Source of enterococci in a farmhouse raw-milk cheese. Appl Environ Microbiol 2002;68(7):3560-3565. The strain used in Symprove is fully characterised and has been subject to whole genome sequencing using recognised methodology, by NCIMB, to confirm identity and provide safety data, unlike other strains with evidence of pathogenicity.4Symprove quality and safety dossier 2017.

The clinical research behind Symprove

Several clinical research studies involving Symprove have been conducted, including randomised, double-blind, placebo-controlled trials, reflecting the level of scientific interest in food supplements containing live and active bacteria. Now there is a new study available, adding to our understanding of microbiota composition. If you would like us to email you a factsheet about these studies, please provide your details here

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The clinical research
behind Symprove

New data roundel yellow

New data roundel yellow

Several clinical research studies involving Symprove have been conducted, including randomised, double-blind, placebo-controlled trials, reflecting the level of scientific interest in food supplements containing live and active bacteria. Now there is a new study available, adding to our understanding of microbiota composition. This PDF features a list of these studies with relevant links.

Several clinical research studies involving Symprove have been conducted, including randomised, double-blind, placebo-controlled trials, reflecting the level of scientific interest in food supplements containing live and active bacteria. This PDF features a list of these studies with relevant links.

Symprove download - The clinical research report
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